Products and Services
Multiple graft options. One streamlined process.
We distribute FDA-cleared advanced wound care products to providers treating chronic wounds.
Our Product Categories
Our portfolio includes dermal, amniotic, membrane, collagen, and synthetic allografts used in the treatment of chronic wounds.
Single Layer
Single-layer allografts consist of a single placental tissue layer, most commonly the amniotic membrane. The amniotic membrane is the innermost layer of the placenta, directly contacting the amniotic fluid, and is the thinnest placental membrane with an approximate thickness of 0.05 mm.
It contains key biomolecules such as collagens I, III, and IV–VI, fibronectin, FGF, VEGF, and EGF. Single-layer amnion allografts are valued for their flexibility, ease of handling, and broad applicability in wound care and ophthalmic treatments.
Interested in Single Layer grafts?
Dual Layer
Dual-layer allografts comprise two layers of placental tissue, either two amniotic membranes or a combination of amnion and chorion. Amnion/amnion allografts are non-directional, allowing either side to contact the wound, while amnion/chorion allografts are directional, with the amnion layer typically facing the wound surface.
The chorion layer, approximately 0.2 mm thick, contains collagens I and III–VI, proteoglycans, fibronectin, ANG, FGF, VEGF, and HGH. The presence of the thicker chorion layer enhances handling properties and structural support compared to dual amnion constructions.
Interested in Dual Layer grafts?
Triple Layer
Triple-layer allografts consist of three layers of placental tissue, typically configured as amnion/amnion/amnion or amnion/chorion/amnion. The latter arrangement provides non-directional application, simplifying placement and use.
The additional layers increase graft thickness and mechanical strength while retaining the beneficial biomolecules inherent to both amnion and chorion membranes. Triple-layer allografts are often selected when additional durability and conformability are desired.
Interested in Triple Layer grafts?
Full Membrane
Full-membrane amniotic allografts include the amnion, intermediate (spongy), and chorion layers, preserving the native, robust extracellular matrix and basement membrane.
These grafts offer the full benefits of the entire placental tissue. Retaining these physiologic layers yields a conformable, easy-to-handle graft that accepts standard fixation and is available in a dehydrated, single-use format—ideal for complex or deeper wounds where a protective covering is needed.
Interested in Full Membrane grafts?
Dermal
Dermal allografts are decellularized human dermis that preserve the native, collagen-rich extracellular matrix, providing strength and conformability for soft-tissue coverage and reinforcement. Their increased thickness offers a larger extracellular matrix for deeper wounds. These grafts handle easily and accept sutures, staples, or adhesive fixation; they’re available in sheet or meshed configurations which allow them to be contour with the wound edge easily.
Interested in Dermal allografts?
Collagen
Collagen allografts are decellularized, bioengineered collagen matrices that preserve a porous, collagen-rich extracellular scaffold, providing conformability and strength for soft-tissue coverage and reinforcement.
Coming from a range of sources, collagen grafts can be selected for their source as well as collagen type. These dehydrated grafts handle easily, hydrate quickly at the wound surface, and accept sutures, staples, or adhesive fixation.
Interested in Collagen allografts?
Synthetic
Synthetic grafts provide a conformable scaffold that maintains a moist environment and serves as a protective barrier for soft-tissue coverage and reinforcement. With unique goals in mind, synthetic grafts can be bioengineered to accomplish things like infection management or covering the micro-textures found in wound beds. These grafts handle easily, are very thin yet durable, and conform well with the wound bed.
Interested in Synthetic grafts?
Blood Derived
Blood-derived grafts are typically autologous, created from the patient’s own blood to minimize the risk of rejection and reduce cost. These grafts may utilize whole blood or fibrin- and platelet-enriched components, forming protective matrices that can be prepared at the bedside. Blood-derived grafts can be trimmed to size or applied directly to the wound surface to promote healing and provide biological protection.
Interested in Blood Derived grafts?
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Amniotic Membrane Allografts
Explore the differences between amniotic layers.
Chorion Layer
The chorion membrane interacts directly with the maternal tissue, allowing for nutrient movement between the maternal tissue and fetal tissue. The chorion has three main layers of a reticular layer, a basement membrane, and trophoblast. The chorion layer is roughly five times thicker than the amnion membrane at approximately 0.2 mm thick. Biomolecules found in the chorion are collagens I and III–VI, proteoglycans, fibronectin, ANG, FGF, VEGF, and HGH. Studies have shown that the chorion membrane also has similar beneficial characteristics as that of the amnion, displaying anti-inflammatory and antimicrobial characteristics.
Intermediate Layer
The intermediate layer is located between the amnion and chorion membranes. It functions as an interface between the fetal facing amnion and the maternal facing chorion membranes. Some biomolecules found in the intermediate layer are collagen I, III, and IV, proteoglycans, and glycoproteins, such as hyaluronic acid and heparan sulfate. The intermediate layer has a physical structure that is spongy-like and acellular.
Amnion Layer
Amnion is the innermost placental membrane tissue. Amnion is composed of epithelium, basement membrane, compact layer, and fibroblast. In the womb the amnion functions as a permeable barrier that allows for transport of nutrients between the maternal tissue and fetal tissue. The amnion membrane is thin, roughly 0.5mm thick, which is mostly the result of compact layer’s thickness. The amnion membrane comprises biomolecules such as collagens I, III, and IV–VI, fibronectin, FGF, VEGF, and EGF. Studies have shown that the amnion membrane has beneficial characteristics of being anti-inflammatory, antimicrobial, and immunologically privileged.
Frequently Asked
Don’t see your question below? Reach out. Our team is ready and waiting to answer any questions you may have.
How many products do you have at AMA?
Advanced Medical Administration (AMA) offers one of the largest portfolios of amniotic and skin-substitute grafts in the nation, representing multiple FDA-registered manufacturers. Our catalog includes both dehydrated and hydrated placental products, as well as collagen-based and synthetic options. We continually expand our offering each quarter to ensure providers have access to the most clinically advanced options available.
What product is most commonly used?
Every wound is unique, and product selection is always guided by medical necessity and the clinical characteristics of the wound. AMA provides a full spectrum of graft options—including single-layer, dual-layer, tri-layer, and full membrane configurations—so that providers can choose the most appropriate solution for each patient. Our goal is to equip you with the right tools to support consistent, high-quality healing outcomes.
Are your products FDA cleared?
All products distributed through AMA are regulated under Section 361 of the Public Health Service Act and the oversight of the U.S. Department of Health and Human Services (HHS). They are processed by FDA-registered tissue banks that comply with the requirements for human cellular and tissue-based products (HCT/Ps). This ensures each graft meets the highest national standards for safety, quality, and ethical sourcing.